Characterization of the 6′- N -Aminoglycoside Acetyltransferase Gene aac(6′)-Iq from the Integron of a Natural Multiresistance Plasmid | Zendy

Daniela Centrón | Zendy; Paul H. Roy | Zendy

Open Access

Characterization of the 6′- N -Aminoglycoside Acetyltransferase Gene aac(6′)-Iq from the Integron of a Natural Multiresistance Plasmid

Author(s) -

Daniela Centrón,

Paul H. Roy

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.6.1506

Subject(s) - integron , genetics , gene , homology (biology) , plasmid , amikacin , gene cassette , biology , nucleic acid sequence , aminoglycoside , microbiology and biotechnology , antibiotics

The nucleotide sequence of a newly identified amikacin resistance gene,aac(6′)-Iq (551 bp), is reported. It has 68.4 and 94.4% homology with theaac(6′)-Ia gene and the recently describedaac(6′)-Ip gene, respectively. Analysis of its flanking sequences indicated that it is in the first cassette of a class I integron and has anattC site (59-base element) 108 bp in length.

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