Efficacies of Zinc-Finger-Active Drugs againstGiardia lamblia | Zendy

Theodore E. Nash | Zendy; William G. Rice | Zendy

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Efficacies of Zinc-Finger-Active Drugs againstGiardia lamblia

Author(s) -

Theodore E. Nash,

William G. Rice

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.6.1488

Subject(s) - disulfiram , giardia lamblia , in vivo , active compound , microbiology and biotechnology , biology , zinc , zinc finger , pharmacology , chemistry , biochemistry , stereochemistry , genetics , organic chemistry , gene , transcription factor

Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 μM or less inhibited the growth ofGiardia lamblia . The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 μM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.

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