Characterization of grlA , grlB , gyrA , and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC | Zendy

FranzJosef Schmitz | Zendy; Mark E. Jones | Zendy; B. Hofmann | Zendy; Birgit Sehested Hansen | Zendy; Sibylle Scheuring | Zendy; Marc Lückefahr | Zendy; Ad C. Fluit | Zendy; J. Verhoef | Zendy; U. Hadding | Zendy; HansPeter Heinz | Zendy; Karl Köhrer | Zendy

Open Access

Characterization of grlA , grlB , gyrA , and gyrB Mutations in 116 Unrelated Isolates of Staphylococcus aureus and Effects of Mutations on Ciprofloxacin MIC

Author(s) -

FranzJosef Schmitz,

Mark E. Jones,

B. Hofmann,

Birgit Sehested Hansen,

Sibylle Scheuring,

Marc Lückefahr,

Ad C. Fluit,

J. Verhoef,

U. Hadding,

HansPeter Heinz,

Karl Köhrer

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.5.1249

Subject(s) - ciprofloxacin , staphylococcus aureus , gene , biology , microbiology and biotechnology , genetics , mutation , dna gyrase , staphylococcus , bacteria , escherichia coli

One hundred sixteen unrelated clinical isolates ofStaphylococcus aureus (70 ciprofloxacin resistant and 46 ciprofloxacin susceptible) from eight countries were studied for the presence of mutations in thegrlA ,grlB ,gyrA , andgyrB gene loci. Two mutations withingrlA (located at codons 80 and 84) and two mutations withingyrA (located at codons 84 and 88) were clearly associated with ciprofloxacin resistance, although other mutations detected within the four genes studied may also contribute to decreased susceptibility.

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