Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry | Zendy

Michael Engler | Zendy; G. Rüsing | Zendy; Fritz Sörgel | Zendy; Ulrike Holzgrabe | Zendy

Open Access

Defluorinated Sparfloxacin as a New Photoproduct Identified by Liquid Chromatography Coupled with UV Detection and Tandem Mass Spectrometry

Author(s) -

Michael Engler,

G. Rüsing,

Fritz Sörgel,

Ulrike Holzgrabe

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.5.1151

Subject(s) - sparfloxacin , chemistry , chromatography , tandem mass spectrometry , mass spectrometry , liquid chromatography–mass spectrometry , derivative (finance) , high performance liquid chromatography , tandem , ultraviolet , ofloxacin , materials science , optoelectronics , composite material , biochemistry , ciprofloxacin , financial economics , economics , antibiotics

Photodegradation of sparfloxacin was observed by means of high-pressure liquid chromatography with UV detection and liquid chromatography coupled with UV detection and tandem mass spectrometry (LC-MS/MS). Three products were detected. Comparison with an independently synthesized derivative of sparfloxacin revealed the structure of one product which is believed to be 8-desfluorosparfloxacin. The second product is likely to be formed by the splitting off of a fluorine and a cyclopropyl ring. Thus, photodefluorination of quinolone antibacterial agents is found and proved for the first time by LC-MS/MS.

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