In Vitro Activity of Levofloxacin against a Selected Group of Anaerobic Bacteria Isolated from Skin and Soft Tissue Infections | Zendy

Hannah M. Wexler | Zendy; E Molitoris | Zendy; Denise Molitoris | Zendy; Sydney M. Finegold | Zendy

Open Access

In Vitro Activity of Levofloxacin against a Selected Group of Anaerobic Bacteria Isolated from Skin and Soft Tissue Infections

Author(s) -

Hannah M. Wexler,

E Molitoris,

Denise Molitoris,

Sydney M. Finegold

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.4.984

Subject(s) - levofloxacin , ofloxacin , ciprofloxacin , cefoxitin , sulbactam , microbiology and biotechnology , ampicillin , metronidazole , anaerobic bacteria , veillonella , pharmacology , medicine , chemistry , antibiotics , biology , bacteria , streptococcus , antibiotic resistance , genetics , imipenem , staphylococcus aureus

The in vitro activity of levofloxacin was compared to the activities of ofloxacin, ciprofloxacin, ampicillin-sulbactam (2:1), cefoxitin, and metronidazole for a selected group of anaerobes (n = 175) isolated from skin and soft tissue infections by using the National Committee for Clinical Laboratory Standards-approved Wadsworth method. Ampicillin-sulbactam and cefoxitin inhibited 99% of the strains of this select group, levofloxacin and ofloxacin inhibited 73 and 50%, respectively, at 2 μg/ml, and ciprofloxacin inhibited 51% at 1 μg/ml. The geometric mean MIC of levofloxacin was lower than those of ofloxacin and ciprofloxacin for every group exceptVeillonella.

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