Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides | Zendy

Wenqiu Liu | Zendy; Xuejun Liu | Zendy; David B. Knaebel | Zendy; Linda A. Luck | Zendy; Yuzhou Li | Zendy

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Synthesis and Antibacterial Evaluation of Novel Water-Soluble Organic Peroxides

Author(s) -

Wenqiu Liu,

Xuejun Liu,

David B. Knaebel,

Linda A. Luck,

Yuzhou Li

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.4.911

Subject(s) - chemistry , antibacterial activity , oxidizing agent , bromide , peroxide , antimicrobial , benzoyl peroxide , moiety , organic chemistry , antibacterial agent , solubility , bacteria , antibiotics , biochemistry , genetics , polymerization , biology , polymer

A set of new water-soluble organic peroxides has been synthesized and evaluated for in vitro antibacterial activity as part of an effort to develop new antibacterial agents for the treatment of acne vulgaris. The water solubility of these new dialkyl peroxides and peroxyesters was achieved by incorporating either a quaternary ammonium group or a polyethylene glycol moiety. These peroxides are effective against both gram-positive and gram-negative bacteria and have a prolonged activity compared to that of benzoyl peroxide and other peroxide-type antiseptic agents. Among them 4-[[(tert -butylperoxy)carbonyl]benzyl]triethylammonium chloride and [10-(tert -butylperoxy)decyl]trimethylammonium bromide have the broadest antimicrobial spectrums. We have shown that the oxidizing properties of the dioxy group of these compounds are responsible for their antibacterial activities.

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