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Genomic diversity of mutation in themecI gene ormecA promoter/operator region was analyzed for clinical isolates of methicillin-resistantStaphylococcus aureus (MRSA) andStaphylococcus epidermidis (MRSE). In most MRSA strains, a single base substitution was detected in either themecI (three different positions) or themecA promoter (two different positions), while a 28-base deletion inmecI was found in one strain. In contrast, no mutation was detected in these gene sequences of MRSE strains.

antimicrobial agents and chemotherapy

Analysis of Diversity of Mutations in the mecI Gene and mecA Promoter/Operator Region of Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis