In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates | Zendy

M. Hong Nguyen | Zendy; Christine Yu | Zendy

Open Access

In Vitro Comparative Efficacy of Voriconazole and Itraconazole against Fluconazole-Susceptible and -Resistant Cryptococcus neoformans Isolates

Author(s) -

M. Hong Nguyen,

Christine Yu

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.2.471

Subject(s) - itraconazole , voriconazole , fluconazole , cryptococcus neoformans , microbiology and biotechnology , biology , in vitro , fungi imperfecti , antifungal , biochemistry

In vitro susceptibility testing for 50 clinical isolates of fluconazole-susceptible or -resistantCryptococcus neoformans was performed with itraconazole and voriconazole. Voriconazole was more potent than itraconazole for fluconazole-susceptible isolates and as potent as itraconazole for fluconazole-susceptible dose-dependent isolates and for fluconazole-resistant isolates. For fluconazole-resistant isolates, the voriconazole and itraconazole MICs ranged from 1 to 2 μg/ml.

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