Immunomodulating Effects of HMR 3004 on Pulmonary Inflammation Caused by Heat-Killed Streptococcus pneumoniae in Mice | Zendy

Michel Duong | Zendy; Marie Simard | Zendy; Yves Bergeron | Zendy; Nathalie Ouellet | Zendy; Mélanie Côté-Richer | Zendy; Michel G. Bergeron | Zendy

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Immunomodulating Effects of HMR 3004 on Pulmonary Inflammation Caused by Heat-Killed Streptococcus pneumoniae in Mice

Author(s) -

Michel Duong,

Marie Simard,

Yves Bergeron,

Nathalie Ouellet,

Mélanie Côté-Richer,

Michel G. Bergeron

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.12.3309

Subject(s) - streptococcus pneumoniae , inflammation , phagocytosis , bronchoalveolar lavage , pneumonia , ketolide , lung , microbiology and biotechnology , immunology , antimicrobial , antibiotics , biology , medicine

We investigated the influence of HMR 3004, a new ketolide antibiotic, on the pulmonary inflammation induced by heat-killed fluorescein isothiocyanate-labeledStreptococcus pneumoniae . HMR 3004 downregulated (P < 0.05) the pneumococcus-induced release of interleukin-6 (IL-6), IL-1β, and nitric oxide in bronchoalveolar lavage fluid. The drug limited (P < 0.05) neutrophil recruitment to lung tissues and alveoli but did not interfere with phagocytosis. HMR 3004 totally abrogated lung edema. By reducing inflammation in addition to possessing antimicrobial properties, HMR 3004 may participate in improving the outcome of bacterial pneumonia.

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