Joint Tolerance to β-Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA | Zendy

Timothy J. Falla | Zendy; Ian Chopra | Zendy

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Joint Tolerance to β-Lactam and Fluoroquinolone Antibiotics in Escherichia coli Results from Overexpression of hipA

Author(s) -

Timothy J. Falla,

Ian Chopra

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.12.3282

Subject(s) - antibiotics , escherichia coli , multidrug tolerance , microbiology and biotechnology , bacteria , biology , enterobacteriaceae , genetics , gene , biofilm

The basis of joint tolerance to β-lactam and fluoroquinolone antibiotics inEscherichia coli mediated byhipA was examined. An antibiotic tolerance phenotype was produced by overexpression ofhipA under conditions that did not affect the growth rate of the organism. OverexpressinghipA probably decreases the period in which bacteria are susceptible to the antibiotics by temporarily affecting some aspect of chromosome replication or cell division.

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