Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-Dalfopristin against Gram-Positive and -Negative Organisms | Zendy

Glenn A. Pankuch | Zendy; Michael R. Jacobs | Zendy; Peter C. Appelbaum | Zendy

Open Access

Postantibiotic Effect and Postantibiotic Sub-MIC Effect of Quinupristin-Dalfopristin against Gram-Positive and -Negative Organisms

Author(s) -

Glenn A. Pankuch,

Michael R. Jacobs,

Peter C. Appelbaum

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.11.3028

Subject(s) - dalfopristin , quinupristin , microbiology and biotechnology , enterococcus faecium , enterococcus , gram , virginiamycin , vancomycin , biology , antibacterial agent , antibiotics , staphylococcus aureus , bacteria , genetics

Quinupristin-dalfopristin produced postantibiotic effects (PAEs) and postantibiotic sub-MIC effects of >2 h against 18 gram-positive cocci. Mean pneumococcal and staphylococcal PAEs were 2.8 and 4.7 h, respectively, with shorter PAEs for constitutively than inducibly macrolide-resistant staphylococci. Mean PAEs for vancomycin-susceptible and -resistantEnterococcus faecium were 8.5 and 2.6 h, respectively.

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