Characterization of Erythromycin-Resistant Isolates of Staphylococcus aureus Recovered in the United States from 1958 through 1969 | Zendy

Federico Nicola | Zendy; Linda K. McDougal | Zendy; James W. Biddle | Zendy; Fred C. Tenover | Zendy

Open Access

Characterization of Erythromycin-Resistant Isolates of Staphylococcus aureus Recovered in the United States from 1958 through 1969

Author(s) -

Federico Nicola,

Linda K. McDougal,

James W. Biddle,

Fred C. Tenover

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.11.3024

Subject(s) - erythromycin , staphylococcus aureus , clindamycin , microbiology and biotechnology , biology , plasmid , gene , virology , antibiotics , genetics , bacteria

We tested 16 erythromycin-resistant clinical isolates ofS. aureus , recovered from patients hospitalized in the United States from 1958 to 1969, for the presence ofermA ,ermB , andermC by using PCR. Fifteen of 16 isolates contained at least one copy ofermA ; the remaining isolate, which was also clindamycin resistant, containedermB . Eight of the 15 isolates harboringermA , all of which were inducible, contained a single copy of the gene in the chromosome, while the remaining seven isolates had two copies of the gene.ermB was plasmid encoded and mediated constitutive resistance to erythromycin.

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