Comparison of CO 2 Generation (BACTEC) and Viable-Count Methods To Determine the Postantibiotic Effect of Antimycobacterial Agents against Mycobacterium avium Complex | Zendy

George G. Zhanel | Zendy; Marilyn H. Saunders | Zendy; Joyce Wolfe | Zendy; Daryl J. Hoban | Zendy; James A. Karlowsky | Zendy; Amin Kabani | Zendy

Open Access

Comparison of CO ₂ Generation (BACTEC) and Viable-Count Methods To Determine the Postantibiotic Effect of Antimycobacterial Agents against Mycobacterium avium Complex

Author(s) -

George G. Zhanel,

Marilyn H. Saunders,

Joyce Wolfe,

Daryl J. Hoban,

James A. Karlowsky,

Amin Kabani

Publication year - 1998

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.42.1.184

Subject(s) - clofazimine , antimycobacterial , ethambutol , mycobacterium avium complex , rifabutin , microbiology and biotechnology , amikacin , mycobacterium , antibacterial agent , mycobacterium chelonae , chemistry , biology , antibiotics , clarithromycin , mycobacterium tuberculosis , medicine , bacteria , rifampicin , tuberculosis , immunology , pathology , leprosy , genetics

The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method againstMycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2× the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research