In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis | Zendy

Christophe Hennequin | Zendy; N Benailly | Zendy; C Silly | Zendy; M Sorin | Zendy; P. Scheinmann | Zendy; G. Lenoir | Zendy; JeanLouis Gaillard | Zendy; Patrick Berche | Zendy

Open Access

In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis

Author(s) -

Christophe Hennequin,

N Benailly,

C Silly,

M Sorin,

P. Scheinmann,

G. Lenoir,

JeanLouis Gaillard,

Patrick Berche

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.9.2064

Subject(s) - miconazole , amphotericin b , itraconazole , microbiology and biotechnology , cystic fibrosis , broth microdilution , antimicrobial , aspergillus , biology , minimum inhibitory concentration , antifungal , genetics

The antimicrobial activities of amphotericin B, itraconazole, and miconazole against 101 filamentous fungi from patients with cystic fibrosis were tested by a reproducible microdilution method. Itraconazole was very active against Aspergillus species and Scedosporium species (MIC at which 90% of the isolates were inhibited [MIC90], 0.06 to 0.5 mg/liter), whereas amphotericin B was less effective (MIC90, 0.5 to 8 mg/liter).

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