Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens | Zendy

George A. Jacoby | Zendy; P Han | Zendy; John H. Tran | Zendy

Open Access

Comparative in vitro activities of carbapenem L-749,345 and other antimicrobials against multiresistant gram-negative clinical pathogens

Author(s) -

George A. Jacoby,

P Han,

John H. Tran

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.8.1830

Subject(s) - klebsiella pneumoniae , imipenem , antimicrobial , microbiology and biotechnology , carbapenem , antibiotics , gram , antibacterial agent , biology , medicine , bacteria , antibiotic resistance , escherichia coli , biochemistry , genetics , gene

Carbapenems L-749,345 and imipenem had the lowest MICs at which 90% of isolates were inhibited (0.5 microg/ml) of 14 antimicrobial agents tested against 76 multiresistant gram-negative clinical isolates with TEM- or SHV-type extended-spectrum beta-lactamases and chromosomal or plasmid-determined AmpC beta-lactamases, but the MIC of L-749,345 for one isolate of Klebsiella pneumoniae was 16 microg/ml.

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