Open AccessAntibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa
Author(s) -
R. C. Li,
Zhaoming Zhu,
S. W. Lee,
Kenneth Raymond,
J. M. Ling,
A. F. B. Cheng
Publication year - 1997
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.41.8.1808
Subject(s) - tobramycin , pseudomonas aeruginosa , minimum inhibitory concentration , antibiotics , microbiology and biotechnology , antimicrobial , pharmacokinetics , pseudomonadaceae , antibacterial agent , minimum bactericidal concentration , aminoglycoside , chemistry , pseudomonas , pseudomonadales , biology , bacteria , pharmacology , gentamicin , genetics
In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.