Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa | Zendy

R C Li | Zendy; Ziyue Zhu | Zendy; S W Lee | Zendy; K Raymond | Zendy; J Ling | Zendy; A. F. B. Cheng | Zendy

Open Access

Antibiotic exposure and its relationship to postantibiotic effect and bactericidal activity: constant versus exponentially decreasing tobramycin concentrations against Pseudomonas aeruginosa

Author(s) -

R C Li,

Ziyue Zhu,

S W Lee,

K Raymond,

J Ling,

A. F. B. Cheng

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.8.1808

Subject(s) - tobramycin , pseudomonas aeruginosa , minimum inhibitory concentration , antibiotics , microbiology and biotechnology , antimicrobial , pharmacokinetics , pseudomonadaceae , antibacterial agent , minimum bactericidal concentration , aminoglycoside , chemistry , pseudomonas , pseudomonadales , biology , bacteria , pharmacology , gentamicin , genetics

In vitro postantibiotic effects (PAEs) exhibited by a standard strain of Pseudomonas aeruginosa following exposure to tobramycin at constant concentrations were compared to those at exponentially decreasing concentrations. Exposure to a constant concentration showed more extensive bacterial killing and resulted in longer PAEs at comparable areas under the concentration-time curves above the MIC. This phenomenon suggests a significant contribution of pharmacokinetics to antimicrobial pharmacodynamics.

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