In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections | Zendy

Takashi Deguchi | Zendy; Takeshi Kawamura | Zendy; Mitsuru Yasuda | Zendy; Masahiro Nakano | Zendy; Hideyuki Fukuda | Zendy; Hisakazu Kato | Zendy; Naoki Kato | Zendy; Yukio Okano | Zendy; Yukimichi Kawada | Zendy

Open Access

In vivo selection of Klebsiella pneumoniae strains with enhanced quinolone resistance during fluoroquinolone treatment of urinary tract infections

Author(s) -

Takashi Deguchi,

Takeshi Kawamura,

Mitsuru Yasuda,

Masahiro Nakano,

Hideyuki Fukuda,

Hisakazu Kato,

Naoki Kato,

Yukio Okano,

Yukimichi Kawada

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.7.1609

Subject(s) - klebsiella pneumoniae , quinolone , microbiology and biotechnology , efflux , in vivo , drug resistance , urinary system , biology , enterobacteriaceae , antibacterial agent , antibiotics , escherichia coli , gene , biochemistry , genetics , endocrinology

We report two cases of failure of fluoroquinolone treatment of urinary tract infections with Klebsiella pneumoniae strains harboring quinolone resistance-associated alterations in GyrA and ParC and in vivo selection of posttreatment isolates with enhanced fluoroquinolone resistance. Active efflux leading to decreased accumulation of a drug enhanced fluoroquinolone resistance in one posttreatment isolate, and an additional mutation in parC resulting in an additional amino acid change in ParC was associated with increased resistance in the other.

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