Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole | Zendy

U Natarajan | Zendy; Elmer Brummer | Zendy; David A. Stevens | Zendy

Open Access

Effect of granulocyte colony-stimulating factor on the candidacidal activity of polymorphonuclear neutrophils and their collaboration with fluconazole

Author(s) -

U Natarajan,

Elmer Brummer,

David A. Stevens

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.7.1575

Subject(s) - granulocyte , candida albicans , fluconazole , granulocyte colony stimulating factor , microbiology and biotechnology , in vitro , colony stimulating factor , colony forming unit , chemistry , pharmacology , antifungal , immunology , medicine , biology , biochemistry , haematopoiesis , chemotherapy , bacteria , genetics , stem cell

The effect of granulocyte colony-stimulating factor (GCSF) treatment of polymorphonuclear neutrophils (PMN) in vitro was studied with respect to their candidacidal activity. The candidacidal activity of PMN was found to be significantly increased when they were pretreated with GCSF. Fluconazole (1 microg/ml) was found to be highly fungistatic (90%) for Candida albicans Sh27 and collaborated with PMN for significantly increased killing. Collaborative killing by PMN significantly increased when they were treated with GCSF before and after fungal exposure. The enhancing activities of GCSF required optimization of the GCSF dose and were thus inoculum and strain dependent.

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