In vitro assessment of the effect of clavulanic acid at concentrations achieved in human serum on the bactericidal activity of amoxicillin at physiological concentrations against Staphylococcus aureus: implications for dosage regimens | Zendy

L. Aguilar | Zendy; María Teresa Martín-Gómez | Zendy; I P Balcabao | Zendy; Marı́a Luisa Gómez-Lus | Zendy; Rafael Dal−Ré | Zendy; Josué Prieto Prieto | Zendy

Open Access

In vitro assessment of the effect of clavulanic acid at concentrations achieved in human serum on the bactericidal activity of amoxicillin at physiological concentrations against Staphylococcus aureus: implications for dosage regimens

Author(s) -

L. Aguilar,

María Teresa Martín-Gómez,

I P Balcabao,

Marı́a Luisa Gómez-Lus,

Rafael Dal−Ré,

Josué Prieto Prieto

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.6.1403

Subject(s) - staphylococcus aureus , clavulanic acid , amoxicillin , in vitro , microbiology and biotechnology , chemistry , antibiotics , antibacterial agent , serum concentration , micrococcaceae , amoxicillin/clavulanic acid , pharmacology , medicine , bacteria , biology , biochemistry , genetics

The effects on Staphylococcus aureus viability and beta-lactamase activity of concentrations that simulated those in human serum after a combined dose of 875 mg of amoxicillin and 125 mg of clavulanic acid were studied in an in vitro pharmacodynamic model. Six hours of preexposure to concentrations of the amoxicillin-clavulanic acid combination that were higher than the amoxicillin-clavulanic acid MIC led to a reduction of the initial inoculum of >90% and to a significant decrease of beta-lactamase activity versus those of the control even from 6 h, when concentrations were subinhibitory. The postantibiotic effect and post-beta-lactamase inhibitor effect contributed to these results.

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