Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae | Zendy

Bruno Périchon | Zendy; Jacques Tankovic | Zendy; Patrice Courvalin | Zendy

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Characterization of a mutation in the parE gene that confers fluoroquinolone resistance in Streptococcus pneumoniae

Author(s) -

Bruno Périchon,

Jacques Tankovic,

Patrice Courvalin

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.5.1166

Subject(s) - streptococcus pneumoniae , topoisomerase iv , microbiology and biotechnology , biology , mutation , streptococcaceae , mutant , antibacterial agent , gene , dna gyrase , genetics , escherichia coli , antibiotics

We report a mutation in the parE genes of two in vitro mutants of Streptococcus pneumoniae responsible for low-level resistance to fluoroquinolones. Sequential acquisition of mutations in parE and gyrA leads to higher levels of resistance. This confirms that topoisomerase IV is the primary target of fluoroquinolones in S. pneumoniae.

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