Heterogeneous expression of glycopeptide resistance in enterococci associated with transfer of vanB | Zendy

Mary K. Hayden | Zendy; Roger N. Picken | Zendy; D F Sahm | Zendy

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Heterogeneous expression of glycopeptide resistance in enterococci associated with transfer of vanB

Author(s) -

Mary K. Hayden,

Roger N. Picken,

D F Sahm

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.4.872

Subject(s) - glycopeptide , microbiology and biotechnology , streptococcaceae , biology , vancomycin , enterococcus , bacteria , antibacterial agent , genetics , staphylococcus aureus , antibiotics

In mating experiments using a clinical strain that constitutively expresses vanB-encoded glycopeptide resistance, resistance transfer was detectable at a frequency of <10(-7) transconjugants/donor. Vancomycin MICs for transconjugants were 2- to 10-fold lower than those for the donor; both inducibly and constitutively resistant transconjugants were obtained. These findings demonstrate that the transfer of vanB among enterococci can be associated with substantial alterations in the level and control of glycopeptide resistance expression.

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