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Fluvastatin, a cholesterol-lowering drug, exhibited minimal activity (MICs of 64 to &gt;128 microg/ml) against Candida species and Cryptococcus neoformans. When fluvastatin was combined with fluconazole or itraconazole, both synergistic and additive effects were noted (fractional inhibitory concentration indices of &lt; or = 0.156 to 0.625; fractional lethal concentration indices of &lt; or = 0.156 to 0.75). This combined fungicidal activity was confirmed by time-versus-killing studies.

antimicrobial agents and chemotherapy

In vitro activity of fluvastatin, a cholesterol-lowering agent, and synergy with flucanazole and itraconazole against Candida species and Cryptococcus neoformans