Comparison of the in vitro activities of Bay 12-8039, a new quinolone, and other antimicrobials against clinically important anaerobes | Zendy

K E Aldridge | Zendy; Deborah Ashcraft | Zendy

Open Access

Comparison of the in vitro activities of Bay 12-8039, a new quinolone, and other antimicrobials against clinically important anaerobes

Author(s) -

K E Aldridge,

Deborah Ashcraft

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.3.709

Subject(s) - cefoxitin , quinolone , ofloxacin , ciprofloxacin , bay , metronidazole , penicillin , cefotetan , microbiology and biotechnology , antimicrobial , antibiotics , pharmacology , biology , chemistry , bacteria , staphylococcus aureus , civil engineering , engineering , genetics

Bay 12-8039, a new 8-methoxy quinolone, was compared with other agents for activity against clinically relevant anaerobes. Bay 12-8039 inhibited 91 and 96% of the 410 test isolates at 2 and 4 micrograms/ml, respectively. Bay 12-8039 had activity comparable to that metronidazole and overall was at least 16-fold more active than ciprofloxacin, ofloxacin, and cefoxitin, 32-fold more active than cefotetan, and at least 128-fold more active than penicillin G.

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