Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae | Zendy

Takashi Deguchi | Zendy; A Fukuoka | Zendy; Mitsuru Yasuda | Zendy; Masahiro Nakano | Zendy; S Ozeki | Zendy; Emiko Kanematsu | Zendy; Yoshinori Nishino | Zendy; Satoshi Ishihara | Zendy; Yoshihito Ban | Zendy; Yukimichi Kawada | Zendy

Open Access

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV in quinolone-resistant clinical isolates of Klebsiella pneumoniae

Author(s) -

Takashi Deguchi,

A Fukuoka,

Mitsuru Yasuda,

Masahiro Nakano,

S Ozeki,

Emiko Kanematsu,

Yoshinori Nishino,

Satoshi Ishihara,

Yoshihito Ban,

Yukimichi Kawada

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.3.699

Subject(s) - dna gyrase , klebsiella pneumoniae , quinolone , topoisomerase iv , biology , microbiology and biotechnology , escherichia coli , gene , virology , protein subunit , antibacterial agent , genetics , antibiotics

We determined a partial sequence of the Klebsiella pneumoniae parC gene, including the region analogous to the quinolone resistance-determining region of the Escherichia coli gyrA gene, and examined 26 clinical strains of K. pneumoniae for an association of alterations in GyrA and ParC with susceptibilities to quinolones. The study suggests that in K. pneumoniae DNA gyrase is a primary target of quinolones and that ParC alterations play a complementary role in the development of higher-level fluoroquinolone resistance.

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