Comparison of in vitro antifungal susceptibilities of conidia and hyphae of filamentous fungi | Zendy

Josep Guarro | Zendy; Carles Llop | Zendy; Carme Aguilar | Zendy; Isabel Pujol | Zendy

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Comparison of in vitro antifungal susceptibilities of conidia and hyphae of filamentous fungi

Author(s) -

Josep Guarro,

Carles Llop,

Carme Aguilar,

Isabel Pujol

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.12.2760

Subject(s) - paecilomyces , miconazole , ketoconazole , hypha , microbiology and biotechnology , itraconazole , biology , conidium , cladosporium , broth microdilution , amphotericin b , fungicide , antifungal , botany , minimum inhibitory concentration , antibiotics , aspergillus

The MICs and minimum fungicidal concentrations (MFCs) of amphotericin B, fluconazole, ketoconazole, flucytosine, miconazole, and itraconazole for 12 isolates of filamentous opportunistic fungi (Scopulariopsis sp., Paecilomyces sp., Cladosporium spp., and Cladophialophora sp.) were determined by a broth microdilution method with hyphal and conidial inocula. With hyphal inocula MICs and MFCs were practically always substantially higher. Only 25% of the 60 MIC comparisons showed discrepancies of twofold or less, while the remaining comparisons showed much larger differences.

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