Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli | Zendy

Anton F. Ehrhardt | Zendy; C. C. Sanders | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Structure-activity studies of quinolone-penems in genetically defined strains of Escherichia coli

Author(s) -

Anton F. Ehrhardt,

C. C. Sanders

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.11.2570

Subject(s) - quinolone , escherichia coli , microbiology and biotechnology , enterobacteriaceae , antimicrobial , biology , antibacterial agent , chemistry , antibiotics , biochemistry , gene

Quinolonyl-beta-lactam antimicrobial agents (QLAs) contain quinolones chemically linked to beta-lactams, although the impact of linkage is poorly understood. Genetically defined Escherichia coli strains were used to determine structure-activity characteristics of three quinolone-penem QLAs. Results suggest that the leaving group resulting from beta-lactam hydrolysis may not be free quinolone.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research