Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa | Zendy

Masahiro Nakano | Zendy; Takashi Deguchi | Zendy; Takeshi Kawamura | Zendy; Mitsuru Yasuda | Zendy; Makoto Kimura | Zendy; Yukio Okano | Zendy; Yukimichi Kawada | Zendy

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Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

Author(s) -

Masahiro Nakano,

Takashi Deguchi,

Takeshi Kawamura,

Mitsuru Yasuda,

Makoto Kimura,

Yukio Okano,

Yukimichi Kawada

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2289

Subject(s) - pseudomonas aeruginosa , microbiology and biotechnology , biology , gene , strain (injury) , pseudomonadaceae , bacteria , antibacterial agent , amino acid , j parc , genetics , antibiotics , beam (structure) , physics , optics , anatomy

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.

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