In vitro evaluation of BO-3482, a novel dithiocarbamate carbapenem with activity against methicillin-resistant staphylococci | Zendy

Yuka Adachi Katayama | Zendy; Keiko Nakamura | Zendy; Yoshihisa Kato | Zendy; N Hazumi | Zendy; Terutaka Hashizume | Zendy; Susumu Nakagawa | Zendy

Open Access

In vitro evaluation of BO-3482, a novel dithiocarbamate carbapenem with activity against methicillin-resistant staphylococci

Author(s) -

Yuka Adachi Katayama,

Keiko Nakamura,

Yoshihisa Kato,

N Hazumi,

Terutaka Hashizume,

Susumu Nakagawa

Publication year - 1997

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.41.10.2282

Subject(s) - imipenem , microbiology and biotechnology , proteus mirabilis , enterococcus faecium , chemistry , carbapenem , staphylococcus aureus , antibiotics , bacteria , biology , antibiotic resistance , genetics

BO-3482, a dithiocarbamate carbapenem, inhibited clinical isolates of methicillin-resistant staphylococci (MRS) at 6.25 microg/ml (MIC at which 90% of isolates tested are inhibited [MIC90]), while the MIC90 of imipenem was > 100 microg/ml. BO-3482 was generally less active than imipenem against methicillin-susceptible Staphylococcus aureus, streptococci, enterococci, and gram-negative bacteria, although BO-3482 showed better activity (MIC90) than imipenem against Enterococcus faecium, Haemophilus influenzae, Proteus mirabilis, and Clostridium difficile. The affinities (50% inhibitory concentrations) of BO-3482 for penicillin-binding protein (PBP) PBP 2' of MRS and PBP 5 of E. faecium (both PBPs have low affinities for ordinary beta-lactam antibiotics) were 3.8 and 20 microg/ml, respectively, reflecting the greater activity of BO-3482 against MRS than against E. faecium.

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