katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients | Zendy

Harri Marttila | Zendy; Hanna Soini | Zendy; Pentti Huovinen | Zendy; Matti K. Viljanen | Zendy

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katG mutations in isoniazid-resistant Mycobacterium tuberculosis isolates recovered from Finnish patients

Author(s) -

Harri Marttila,

Hanna Soini,

Pentti Huovinen,

Matti K. Viljanen

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.9.2187

Subject(s) - inha , mycobacterium tuberculosis , isoniazid , biology , point mutation , missense mutation , rpob , gene , tuberculosis , genetics , mutation , microbiology and biotechnology , virology , medicine , 16s ribosomal rna , pathology

katG and inhA genes from isoniazid-resistant Mycobacterium tuberculosis strains isolated in Finland were examined by PCR or sequencing. By PCR, katG was not detected in 3 of 54 strains. Sequencing of katG from 13 strains showed small point mutations or insertions; a previously described mutation causing a Ser-to-Thr change at position 315 was found in 4 strains, and there were nine new missense mutations of katG. A 209-bp segment of inhA from 17 strains was sequenced, but no mutations were observed. This result indicates that different mutations prevail in different geographical areas.

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