Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster | Zendy

Frank M. Aarestrup | Zendy; Peter Ahrens | Zendy; M. Madsen | Zendy; Lars Pallesen | Zendy; Rikke Lykke Poulsen | Zendy; Henrik Westh | Zendy

Open Access

Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster

Author(s) -

Frank M. Aarestrup,

Peter Ahrens,

M. Madsen,

Lars Pallesen,

Rikke Lykke Poulsen,

Henrik Westh

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.8.1938

Subject(s) - enterococcus faecium , enterococcus faecalis , microbiology and biotechnology , biology , glycopeptide , vancomycin , enterococcus , streptococcaceae , antibacterial agent , transposable element , antibiotics , gene , bacteria , staphylococcus aureus , genetics , mutant

The MICs of vancomycin and avoparcin were determined for isolates of Enterococcus faecium and isolates of Enterococcus faecalis recovered from the feces of humans and animals in Denmark. Two hundred twenty-one of 376 (59%) isolates of E. faecium and 2 of 133 (1.5%) isolates of E. faecalis were resistant to vancomycin (MICs, 128 to > or = 256 micrograms/ml), and all vancomycin-resistant isolates were resistant to avoparcin (MICs, 64 to > or = 256 micrograms/ml). All vancomycin-resistant isolates examined carried the vanA, vanX, and vanR genes, suggesting that a gene cluster similar to that of the transposon Tn1546 was responsible for the resistance.

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