Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2) | Zendy

Maria Gazouli | Zendy; L. S. Tzouvelekis | Zendy; E.E. Prinarakis | Zendy; Vivì Miriagou | Zendy; Εva Tzelepi | Zendy

Open Access

Transferable cefoxitin resistance in enterobacteria from Greek hospitals and characterization of a plasmid-mediated group 1 beta-lactamase (LAT-2)

Author(s) -

Maria Gazouli,

L. S. Tzouvelekis,

E.E. Prinarakis,

Vivì Miriagou,

Εva Tzelepi

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.7.1736

Subject(s) - cefoxitin , plasmid , citrobacter freundii , klebsiella pneumoniae , enterobacter aerogenes , microbiology and biotechnology , escherichia coli , biology , enterobacteriaceae , beta lactamase , enterobacter , bacteria , genetics , gene , staphylococcus aureus

Cefoxitin resistance in Klebsiella pneumoniae from Escherichia coli strains isolated in Greek hospitals was found to be due to the acquisition of similar plasmids coding for group 1 beta-lactamases. The plasmids were not self-transferable but were mobilized by conjugative plasmids. These elements have also been spread to Enterobacter aerogenes. The most common enzyme was a Citrobacter freundii-derived cephalosporinase (LAT-2) which differed from LAT-1 by three amino acids.

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