Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers | Zendy

J G Gillum | Zendy; Debra S. Israel | Zendy; R. B. Scott | Zendy; Michael W. Climo | Zendy; Ron E. Polk | Zendy

Open Access

Effect of combination therapy with ciprofloxacin and clarithromycin on theophylline pharmacokinetics in healthy volunteers

Author(s) -

J G Gillum,

Debra S. Israel,

R. B. Scott,

Michael W. Climo,

Ron E. Polk

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.7.1715

Subject(s) - theophylline , clarithromycin , pharmacokinetics , ciprofloxacin , crossover study , medicine , pharmacology , combination therapy , antibacterial agent , drug interaction , antibiotics , biology , microbiology and biotechnology , pathology , alternative medicine , helicobacter pylori , placebo

Five adults completed this four-way randomized crossover study to compare the effects of oral treatment with ciprofloxacin, clarithromycin, and a combination of the two drugs on theophylline pharmacokinetics. The area under the concentration-time curve for theophylline during combination therapy was not different from that for ciprofloxacin alone. Beta error may explain this finding, but any real effect from combination treatment appears to be clinically unimportant.

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