Eucaryotic cells protect Borrelia burgdorferi from the action of penicillin and ceftriaxone but not from the action of doxycycline and erythromycin | Zendy

Philippe Brouqui | Zendy; Sékéné Badiaga | Zendy; Didier Raoult | Zendy

Open Access

Eucaryotic cells protect Borrelia burgdorferi from the action of penicillin and ceftriaxone but not from the action of doxycycline and erythromycin

Author(s) -

Philippe Brouqui,

Sékéné Badiaga,

Didier Raoult

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.6.1552

Subject(s) - doxycycline , borrelia burgdorferi , ceftriaxone , erythromycin , penicillin , microbiology and biotechnology , antibiotics , lyme disease , borrelia , antibacterial agent , biology , medicine , virology , immunology , antibody

Despite appropriate antibiotic treatment, Lyme disease patients may have relapses or may develop chronic manifestations. The intracellular location of Borrelia burgdorferi suggests that antibiotics that penetrate cells will have greater efficiency. Doxycycline or erythromycin was more effective than penicillin or ceftriaxone in killing B. burgdorferi when the organism was grown in the presence of eucaryotic cells.

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