Indole and (E)-2-hexenal, phytochemical potentiators of polymyxins against Pseudomonas aeruginosa and Escherichia coli | Zendy

Aya Kubo | Zendy; Christopher S. Lunde | Zendy; Isao Kubo | Zendy

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Indole and (E)-2-hexenal, phytochemical potentiators of polymyxins against Pseudomonas aeruginosa and Escherichia coli

Author(s) -

Aya Kubo,

Christopher S. Lunde,

Isao Kubo

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.6.1438

Subject(s) - colistin , polymyxin , antimicrobial , pseudomonas aeruginosa , escherichia coli , microbiology and biotechnology , polymyxin b , potentiator , phytochemical , antibiotics , biology , bacteria , gram negative bacteria , chemistry , pharmacology , biochemistry , genetics , gene

Combinations of polymyxins and phytochemicals were tested for antimicrobial activity against two gram-negative bacteria. Various degrees of potentiation were found against Pseudomonas aeruginosa and Escherichia coli with (E)-2-hexenal and indole. Three-compound combinations were found to further increase the activity of polymyxin B sulfate and colistin methanesulfonate against both bacteria. Combinations with colistin against P. aeruginosa resulted in the highest degree of potentiation, with a 512-fold increase in colistin antimicrobial activity. These results indicate the potential efficacy of phytochemical combinations with antibiotics to enhance total biological activity.

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