Activity of nitric oxide-generating compounds against encephalomyocarditis virus | Zendy

Eric Guillemard | Zendy; Monique GeniteauLegendre | Zendy; R Kergot | Zendy; G. Lemaire | Zendy; J.F. Petit | Zendy; C Labarre | Zendy; Anne-Marie Quéro | Zendy

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Activity of nitric oxide-generating compounds against encephalomyocarditis virus

Author(s) -

Eric Guillemard,

Monique GeniteauLegendre,

R Kergot,

G. Lemaire,

J.F. Petit,

C Labarre,

Anne-Marie Quéro

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.4.1057

Subject(s) - nitric oxide , sodium nitroprusside , virus , glutathione , chemistry , cytotoxic t cell , virology , viral replication , biology , biochemistry , enzyme , in vitro , organic chemistry

Nitric oxide (NO) generated by two NO donors (sodium nitroprusside or S-nitroso-L-glutathione) was shown to exert a dose-dependent inhibition of encephalomyocarditis virus growth in L-929 cells. This activity was not due to the cytotoxic or direct virucidal effects of NO donors. L-929 cells were shown to produce NO endogenously, but this low level of production did not counter encephalomyocarditis virus replication.

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