Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance | Zendy

Olga Lomovskaya | Zendy; Fusako Kawai | Zendy; Abdul Matin | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Differential regulation of the mcb and emr operons of Escherichia coli: role of mcb in multidrug resistance

Author(s) -

Olga Lomovskaya,

Fusako Kawai,

Abdul Matin

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.4.1050

Subject(s) - operon , escherichia coli , multiple drug resistance , efflux , microbiology and biotechnology , biology , drug resistance , chemistry , gene , genetics

The mcb operon (which is responsible for microcin B17 production) and the emr operon (which encodes a multidrug resistance pump) share a common negative regulator, EmrR. Nevertheless, compounds that induce the emr operon repress the mcb operon. The pump dedicated to microcin B17 extrusion can also protect the calls against sparfloxacin and other toxic compounds.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research