Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles | Zendy

Takashi Deguchi | Zendy; Mitsuru Yasuda | Zendy; Masahiro Nakano | Zendy; S Ozeki | Zendy; Takayuki Ezaki | Zendy; Isao Saito | Zendy; Yukimichi Kawada | Zendy

Open Access

Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles

Author(s) -

Takashi Deguchi,

Mitsuru Yasuda,

Masahiro Nakano,

S Ozeki,

Takayuki Ezaki,

Isao Saito,

Yukimichi Kawada

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.4.1020

Subject(s) - neisseria gonorrhoeae , dna gyrase , quinolone , microbiology and biotechnology , biology , topoisomerase iv , cephalosporin , antimicrobial , antibacterial agent , neisseria , neisseriaceae , antibiotics , genetics , bacteria , gene , escherichia coli

Fifty-five clinical strains of Neisseria gonorrhoeae were examined for mutations in the gyrA and parC genes and for antimicrobial susceptibility profiles. The MICs of quinolones for 31 strains with alterations in GyrA were significantly higher than the MICs for 24 strains without such alterations. Eleven strains with alterations in both GyrA and ParC were significantly more resistant to fluoroquinolones than those with alterations in GyrA alone. The MICs of cephalosporins for these strains were also significantly higher than those for other strains.

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