Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis | Zendy

D Vermot | Zendy; José M. Entenza | Zendy; Jacques Vouillamoz | Zendy; M. P. Glauser | Zendy; P. Moreillon | Zendy

Open Access

Efficacy of clarithromycin versus that of clindamycin for single-dose prophylaxis of experimental streptococcal endocarditis

Author(s) -

D Vermot,

José M. Entenza,

Jacques Vouillamoz,

M. P. Glauser,

P. Moreillon

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.3.809

Subject(s) - clarithromycin , clindamycin , endocarditis , medicine , chemoprophylaxis , antibiotics , streptococcus , microbiology and biotechnology , streptococcaceae , antibiotic prophylaxis , antibacterial agent , biology , bacteria , genetics

Clarithromycin is compared with clindamycin for single-dose prophylaxis of streptococcal endocarditis in rats. Human-like kinetics of the two antibiotics prevented endocarditis in animals challenged with both small and large amounts of bacterial inocula. Clarithromycin was marginally superior to clindamycin against small amounts of inocula. Clarithromycin may be considered for endocarditis chemoprophylaxis in human.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research