Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo | Zendy

Peter Hafkemeyer | Zendy; Andrea KepplerHafkemeyer | Zendy; M A al Haya | Zendy; Martin von JantaLipinski | Zendy; Eckart Matthes | Zendy; Christine Lehmann | Zendy; W B Offensperger | Zendy; Silke Offensperger | Zendy; W. Gerok | Zendy; Hubert E. Blum | Zendy

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Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo

Author(s) -

Peter Hafkemeyer,

Andrea KepplerHafkemeyer,

M A al Haya,

Martin von JantaLipinski,

Eckart Matthes,

Christine Lehmann,

W B Offensperger,

Silke Offensperger,

W. Gerok,

Hubert E. Blum

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.3.792

Subject(s) - duck hepatitis b virus , in vivo , in vitro , biology , viral replication , virology , virus , hepadnaviridae , replication (statistics) , hepatitis b virus , microbiology and biotechnology , biochemistry , genetics

The antiviral activity of 2',3'-dideoxy-3'-fluoroguanosine (FdG) or its triphosphate was evaluated in the duck hepatitis B virus (DHBV) system in vitro and in vivo. In primary DHBV-infected hepatocytes FdG results in a dose-dependent inhibition of viral replication with a nearly complete inhibition at a concentration of 1 microM. Also in vivo, FdG treatment of DHBV-infected ducklings reduces DHBV DNA replication by more than 90%. These data demonstrate that FdG is a strong inhibitor of DHBV replication in vitro and in vivo.

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