Investigation of bioequivalence and tolerability of intramuscular ceftriaxone injections by using 1% lidocaine, buffered lidocaine, and sterile water diluents | Zendy

Clare.J. Hayward | Zendy; Anne N. Nafziger | Zendy; S J Kohlhepp | Zendy; Joseph Bertino | Zendy

Open Access

Investigation of bioequivalence and tolerability of intramuscular ceftriaxone injections by using 1% lidocaine, buffered lidocaine, and sterile water diluents

Author(s) -

Clare.J. Hayward,

Anne N. Nafziger,

S J Kohlhepp,

Joseph Bertino

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.2.485

Subject(s) - lidocaine , tolerability , medicine , bioequivalence , pharmacokinetics , diluent , ceftriaxone , anesthesia , pharmacology , chemistry , antibiotics , adverse effect , biochemistry , nuclear chemistry

The pharmacokinetics and tolerability of 1-g doses of ceftriaxone diluted in sterile water, 1% lidocaine, or buffered lidocaine were investigated. No difference in bioequivalence was noted between the three treatments. No difference in peak creatine kinase values was seen. By use of a quantitative pain scale, injection of ceftriaxone with the water diluent was significantly more painful than that with either of the other two diluents. No difference in injection pain was noted for lidocaine or buffered lidocaine.

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