Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci | Zendy

Claudia M. Brandt | Zendy; C B Warner | Zendy; Mark S. Rouse | Zendy; James M. Steckelberg | Zendy; Walter R. Wilson | Zendy

Open Access

Effect of gentamicin dosing interval on efficacy of penicillin or ceftriaxone treatment of experimental endocarditis due to penicillin-susceptible, ceftriaxone-tolerant viridans group streptococci

Author(s) -

Claudia M. Brandt,

C B Warner,

Mark S. Rouse,

James M. Steckelberg,

Walter R. Wilson

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2901

Subject(s) - ceftriaxone , penicillin , medicine , procaine , gentamicin , endocarditis , dosing , antibiotics , anesthesia , pharmacology , microbiology and biotechnology , biology

The efficacy of ceftriaxone or penicillin alone or combined with gentamicin at different dosing intervals was evaluated in experimental endocarditis due to a penicillin-susceptible, ceftriaxone-tolerant strain of Streptococcus sanguis I. The difference between monotherapy with ceftriaxone and procaine penicillin approached statistical significance (P = 0.052). Ceftriaxone combined with gentamicin administered as a single daily dose was less effective than was procaine penicillin combined with gentamicin administered in a single daily dose or in three divided doses.

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