Treatment of enteric fever with pefloxacin for 7 days versus 5 days: a randomized clinical trial | Zendy

Serhat Ünal | Zendy; Mutlu Hayran | Zendy; Serdar Tunçer | Zendy; Deniz Gür | Zendy; Ömrüm Uzun | Zendy; Murat Akova | Zendy; Halis Akalın | Zendy

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Treatment of enteric fever with pefloxacin for 7 days versus 5 days: a randomized clinical trial

Author(s) -

Serhat Ünal,

Mutlu Hayran,

Serdar Tunçer,

Deniz Gür,

Ömrüm Uzun,

Murat Akova,

Halis Akalın

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.12.2898

Subject(s) - pefloxacin , salmonella , medicine , group b , salmonella typhi , group a , antibacterial agent , gastroenterology , oral administration , antibiotics , microbiology and biotechnology , biology , bacteria , ofloxacin , escherichia coli , biochemistry , genetics , ciprofloxacin , gene

In this prospective study of enteric fever, 22 patients received 400 mg of pefloxacin twice daily for 5 days (group A) and 24 received 400 mg of pefloxacin twice daily for 7 days (group B). Causative microorganisms were Salmonella typhi (8 in group A, 11 in group B) and Salmonella paratyphi B (14 in group A, 13 in group B). The clinical cure and bacterial eradication rates were 96% (21 of 22) in group A and 100% in group B. In conclusion, 5-day oral administration of pefloxacin was as effective as 7-day treatment of enteric fever caused by Salmonella spp.

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