Biliary excretion of ciprofloxacin and piperacillin in the obstructed biliary tract | Zendy

Susan Hazel | Zendy; X H de Vries | Zendy; Peter Speelman | Zendy; J. Dankert | Zendy; G. N. J. Tytgat | Zendy; K. Huibregtse | Zendy; Dirk J. van Leeuwen | Zendy

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Biliary excretion of ciprofloxacin and piperacillin in the obstructed biliary tract

Author(s) -

Susan Hazel,

X H de Vries,

Peter Speelman,

J. Dankert,

G. N. J. Tytgat,

K. Huibregtse,

Dirk J. van Leeuwen

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.11.2658

Subject(s) - piperacillin , ciprofloxacin , biliary tract , antibacterial agent , medicine , gastroenterology , excretion , antibiotics , chemistry , biology , genetics , bacteria , pseudomonas aeruginosa , biochemistry

Biliary excretion of ciprofloxacin and piperacillin was determined in cholestatic patients who had undergone endoscopic cholangiography. The median concentration of ciprofloxacin (n = 9) was 2.36 micrograms/ml (range, 0.29 to 19.8 micrograms/ml) in bile compared with 1.66 micrograms/ml (range, 0.73 to 2.69 micrograms/ml) in serum. The median concentration of piperacillin (n = 7) was < 5 micrograms/ml (range, < 5 to 26) in bile compared with 14.3 micrograms/ml (range, 5.3 to 80) in serum. Ciprofloxacin, but not piperacillin, can be actively excreted into bile in the presence of a biliary tract obstruction.

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