Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups | Zendy

Geoffrey A. McKay | Zendy; Juliatiek Roestamadji | Zendy; Shahriar Mobashery | Zendy; Gerard D. Wright | Zendy

Open Access

Recognition of aminoglycoside antibiotics by enterococcal-staphylococcal aminoglycoside 3'-phosphotransferase type IIIa: role of substrate amino groups

Author(s) -

Geoffrey A. McKay,

Juliatiek Roestamadji,

Shahriar Mobashery,

Gerard D. Wright

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.11.2648

Subject(s) - aminoglycoside , antibiotics , phosphotransferase , microbiology and biotechnology , phosphotransferases , enzyme , chemistry , biochemistry , biology

The interactions of the aminoglycoside 3'-phosphotransferase IIIa with aminoglycoside antibiotics lacking specific amino groups were examined by steady-state kinetic analyses. The results demonstrate that an amino group on C-1 and either an amino or a hydroxyl group at the 2' and 6' positions are important for detoxification of aminoglycosides by this enzyme.

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