Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex | Zendy

Lisa M. Shah | Zendy; Steven C. Meyer | Zendy; Michael H. Cynamon | Zendy

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Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex

Author(s) -

Lisa M. Shah,

Steven C. Meyer,

Michael H. Cynamon

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.10.2426

Subject(s) - dapsone , pyrimethamine , microbiology and biotechnology , in vitro , minimum inhibitory concentration , mycobacterium , sulfadiazine , antibacterial agent , pharmacology , chemistry , biology , antibiotics , bacteria , immunology , plasmodium falciparum , malaria , biochemistry , genetics

The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to > 64 micrograms/ml. Pyrimethamine in combination with a fixed concentration of dapsone at 0.5 microgram/ml showed enhanced activity, with an MIC range of 0.5 to 16 micrograms/ml.

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