Differential release of smooth-type lipopolysaccharide from Pseudomonas aeruginosa treated with carbapenem antibiotics and its relation to production of tumor necrosis factor alpha and nitric oxide | Zendy

Takashi Yokochi | Zendy; Akinori Kusumi | Zendy; Nobuo Kido | Zendy; Yasuhiro Kato | Zendy; Tsuyoshi Sugiyama | Zendy; Naoki Koide | Zendy; G.-Z. Jiang | Zendy; K. Narita | Zendy; K. Takahashi | Zendy

Open Access

Differential release of smooth-type lipopolysaccharide from Pseudomonas aeruginosa treated with carbapenem antibiotics and its relation to production of tumor necrosis factor alpha and nitric oxide

Author(s) -

Takashi Yokochi,

Akinori Kusumi,

Nobuo Kido,

Yasuhiro Kato,

Tsuyoshi Sugiyama,

Naoki Koide,

G.-Z. Jiang,

K. Narita,

K. Takahashi

Publication year - 1996

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.40.10.2410

Subject(s) - imipenem , pseudomonas aeruginosa , meropenem , nitric oxide , microbiology and biotechnology , tumor necrosis factor alpha , lipopolysaccharide , antibiotics , bacteria , pseudomonadaceae , pharmacology , chemistry , biology , immunology , antibiotic resistance , endocrinology , genetics

Endotoxin release from Pseudomonas aeruginosa treated with cell wall-active carbapenem antibiotics and its effect on the production of tumor necrosis factor alpha and nitric oxide were examined. Treatment of bacteria with imipenem induced much lower levels of endotoxin release than treatment with meropenem. The endotoxin released was demonstrated to be of the smooth type and O-specific polysaccharide-rich. The exposure of the filtrates of P. aeruginosa treated with imipenem to physiologically relevant cells caused low-level production of tumor necrosis factor alpha and nitric oxide, while similar treatment with meropenem induced high levels of production.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research