Open AccessEvaluation of high-dose regimen of paromomycin against cryptosporidiosis in the dexamethasone-treated rat model
Author(s) -
Renaud Verdon,
J Polianski,
C. Gaudebout,
C Marche,
Louis Garry,
C Carbon,
J J Pocidalo
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.9.2155
Subject(s) - paromomycin , dose , dexamethasone , regimen , pharmacology , medicine , toxicity , antibiotics , aminoglycoside , biology , microbiology and biotechnology
In the dexamethasone-treated rat model of cryptosporidiosis, paromomycin was effective at a dosage of 50 mg/kg/day or more for ileal infection and 200 mg/kg/day or more for cecal infection. At 1 and 3 weeks after treatment, a persistent infection was demonstrated in all rats. These results confirm the anticryptosporidial activity of paromomycin and underscore the limitations of this compound because of its potential toxicity at such high dosages and its inability to eradicate the infection.