Open AccessIn vitro activities of PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite against Mycobacterium avium complex
Author(s) -
Sophie Meyer,
Subhabrata Majumder,
Michael H. Cynamon
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.8.1862
Subject(s) - metabolite , dihydrofolate reductase , in vitro , microbiology and biotechnology , mycobacterium , antibacterial agent , enzyme , enzyme inhibitor , biology , mycobacterium avium complex , active metabolite , biochemistry , chemistry , bacteria , antibiotics , genetics
PS-15, a new dihydrofolate reductase inhibitor, and its cyclic metabolite were evaluated for in vitro activity against 31 clinical Mycobacterium avium complex isolates. Broth dilution MICs of PS-15 ranged from 16 to 64 micrograms/ml. The cyclic metabolite was three to five times more active than the parent compound. Further evaluation of these compounds in an M. avium-infected murine test system will be of interest.