Open AccessRevised interpretation of oxacillin MICs for Staphylococcus epidermidis based on mecA detection
Author(s) -
Christine McDonald,
William E. Maher,
Robert J. Fass
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.4.982
Subject(s) - staphylococcus epidermidis , microbiology and biotechnology , microgram , staphylococcus aureus , antibacterial agent , biology , staphylococcus , sccmec , micrococcaceae , meticillin , minimum inhibitory concentration , antibiotics , bacteria , methicillin resistant staphylococcus aureus , in vitro , biochemistry , genetics
In 1992 and 1993, at The Ohio State University Medical Center, a larger proportion of Staphylococcus epidermidis strains required oxacillin MICs of 1 to 2 micrograms/ml than did Staphylococcus aureus strains. mecA genotype was correlated with antimicrobial susceptibility for selected clinical S. epidermidis strains. All 14 strains that required oxacillin MICs of or = 1.0 microgram/ml were resistant by oxacillin disk test and were mecA positive. Current National Committee for Clinical Laboratory Standards MIC interpretive criteria may underestimate methicillin resistance among S. epidermidis strains.