Open AccessKilling activity of cefpirome against penicillin-resistant Streptococcus pneumoniae isolates from patients with meningitis in a pharmacodynamic model simulating the cerebrospinal fluid concentration profile
Author(s) -
F. Fitoussi,
Catherine Doit,
Anna Sandin,
A. Péchinot,
A Kazmierczack,
P. Geslin,
Édouard Bingen
Publication year - 1995
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.39.11.2560
Subject(s) - cefpirome , penicillin , streptococcus pneumoniae , microbiology and biotechnology , meningitis , microgram , antibiotics , cerebrospinal fluid , minimum inhibitory concentration , chemistry , antibacterial agent , pharmacodynamics , pharmacokinetics , pharmacology , medicine , in vitro , biology , surgery , antibiotic resistance , biochemistry , imipenem
An in vitro pharmacodynamic model was used to determine the killing kinetics of cefpirome against 20 Streptococcus pneumoniae strains (penicillin G MICs, > 0.125 to 2 micrograms/ml) isolated from patients with meningitis. The concentration of cefpirome was adjusted dynamically to simulate the median concentration profile obtained in the cerebrospinal fluid of adults after the infusion of a single dose of 2 g. The cefpirome MIC at which 90% of isolates are inhibited was 0.5 microgram/ml. Bactericidal activity was observed at 6 h, with mean killing of 3.51 +/- 0.34 log10 CFU/ml for all strains for which the cefpirome MIC was or = 0.5 microgram/ml, killing was significantly less (P < 0.05), with a mean reduction of only 2.86 +/- 0.57 log10 CFU/ml.